The Simpsons looked to have killed Dr. Nick in the 2007 movie, but couldn't resist bringing the inept physician back to the TV show. Ever. Distraught Heidi, 58, thinks the groundbreaking Pfizer-BioNtech vaccine may have somehow been the trigger. The episode " Sweets and Sour Marge " was dedicated to him. Two of the most famous examples include Maude Flanders' darkly comedic death at a sports game, indirectly caused by Homer, and the demise of Bleeding Gums Murphy, Lisa's jazz inspiration. Bleeding Gums: "I don't really have a family, all I had was a little brother who grew up to become a doctor. Three weeks ago, I wrote about how the roll out of COVID-19 vaccines under the FDA’s emergency use authorization (EUA) for the Pfizer/BioNTech and Moderna RNA-based vaccines would very likely result in a tsunami of confusion of correlation with causation to blame the vaccines on all manner of seeming “adverse events,” whether the adverse events were caused by the vaccine or not. Pfizer told DailyMail.com Wednesday that it was aware of Dr. Michael’s ‘highly unusual’ death and was investigating further. However he died from a hemorrhagic stroke – when blood from an artery bleeds into the brain – before he could undergo the surgery. Even people who have severe forms of chronic ITP can live for decades. For more on how, when studying adverse events after vaccination, scientists differentiate coincidence from actual association that might be causal, here’s a good primer. When rituximab binds to CD20, it causes B-cell death and is used against blood cancers and autoimmune diseases. We do not know if Dr. Michael’s case, as tragic as it is, even indicates potential causation. In cases of refractory ITP, thrombopoietin receptor agonists (drugs that stimulate the receptor) can stimulate the bone marrow to make more platelets. Round Springfield" is the 22nd episode of The Simpsons ' sixth season. Be that as it may, another later study noted that bleeding episodes were uncommon among these patients, that the ITP associated with MMR disappeared within a month in 74% patients and only persisted beyond 6 months in only 10%. Either way, platelet transfusions are not a long-term treatment for ITP, as they can only temporarily increase the number of functional platelets. Unfortunately, Dr. Michael’s case is, at present, a single anecdote, making it impossible to demonstrate causation. There are also other drugs that can be used, non-steroid immunosuppressants such as mycophenolate mofetil and azathioprine, or even the chemotherapy agent vincristine. Thus, platelet infusions are generally not used except in emergencies when bleeding is occurring or platelet counts are as low as Dr. Michael’s were. ... We did a lot of work for him including building the seat he is sitting on in … When Bart and Homer destroy the giant glass dome covering Springfield, a large shard of the broken shell falls to the ground and impales Dr. Nick right through the road. What the story means by “had no choice” was the surgical treatment of ITP, namely splenectomy, or removal of the spleen. Dr. Gregory Michael, 56, an OB-GYN at Mount Sinai Medical Center in Miami Beach, died after suffering a hemorrhagic stroke apparently resulting from a lack of platelets. Bleeding Gums Murphy tells Lisa about his Fabergé egg addiction. This seemed to confirm that the character had been written out of the series. He was married to Deborah Sharpe-Taylor. That means that, in any given three day period (chosen because Dr. Michael’s wife reported that her husband’s symptoms began three days after he was vaccinated with the Pfizer/BioNTech COVID vaccine), one would expect approximately 48 adults to be diagnosed with ITP. He used to laugh at the most inappropriate times." Oh well, bye, bye." In the case of Maude Flanders and Bleeding Gums, both exits were major plot points that reverberated through other characters and bled into later episodes; to undo either of those would've cheapened the impact of the deaths. Exploring issues and controversies in the relationship between science and medicine. As I mentioned above, ITP is an autoimmune condition that results in platelet destruction in the spleen. He would not eat for (2) days but he was drinking water profusly then throw it up. Despite being a reliable source of gags, the 2007 Simpsons movie appeared to kill off Dr. Nick. There will be people who get COVID-19 right after having the vaccine, and antivaxxers will claim that the vaccine caused it, just as they sometimes claim that the flu vaccine causes the flu. This brings us, after this long detour into the weeds of what ITP is, what can trigger it, and how it’s treated, back to the question of COVID-19 vaccination and ITP, the question at the heart of the sad story of Dr. Michael’s sudden development of ITP refractory to treatment that claimed his life within two weeks of diagnosis. The Simpsons has killed off a few characters over the years, including Dr. Nick, the world's worst physician, but the writers soon brought him back. My mom took my cat to an emergency vet due to bleeding of the mouth/gums that started 2 days ago. Occasional bleeding of the gums can … Nosebleeds and bleeding gums; Prolonged bleeding from cuts; Skin rash; Dizziness; Headache; Yeah Kaori seemed to have most of these symptoms except Nosebleeds, bleeding gums and skin rash. Dr. Nick's revival isn't an isolated case in The Simpsons. Then he bled to death between midnight an five this morning. Here’s the first story of a death after vaccination against COVID-19 that sounds plausible on the surface that allows me to revisit this issue because, unlike the cases of people who are, for example, hit by a car within two weeks of vaccination, we can’t just dismiss it a priori: A Florida doctor has died several weeks after receiving a COVID-19 vaccine, although it’s not yet clear whether his death Monday was related to the shot he received on Dec. 18. A Florida doctor has died several weeks after receiving a COVID-19 vaccine, although it’s not yet clear whether his death Monday was related to the shot he received on Dec. 18. It’s always a pleasure to re-watch episodes of the Best. The story also noted that ITP “can also be caused by cancer, anemia, heavy drinking, viruses, some genetic conditions, toxic chemicals and medications such as diuretics and the rarely used antibiotic chloramphenicol”. 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